NBD-556

NBD-556, a CD4 mimetic, is a potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction. NBD-556 shows potent cell fusion and virus-cell fusion inhibitory activity at low micromolar levels[1][2].

Product Specifications

CAS Number

[333353-44-9]

UNSPSC

12352005

Hazard Statement

H301

Target

HIV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/nbd-556.html

Purity

99.57

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

O=C(C(NC1CC(C)(NC(C)(C1)C)C)=O)NC2=CC=C(C=C2)Cl

Molecular Formula

C17H24ClN3O2

Molecular Weight

337.84

Precautions

H301

References & Citations

[1]Schon A, et al. Thermodynamics of binding of a low-molecular-weight CD4 mimetic to HIV-1 gp120. Biochemistry. 2006 Sep 12;45 (36) :10973-10980.|[2]Zhao Q, Ma L, Jiang S, Lu H, Liu S, He Y, Strick N, Neamati N, Debnath AK. Identification of N-phenyl-N'- (2,2,6,6-tetramethyl-piperidin-4-yl) -oxalamides as a new class of HIV-1 entry inhibitors that prevent gp120 binding to CD4. Virology. 2005 Sep 1;339 (2) :213-25.