Tau isoform 4 Monoclonal Antibody, APC Conjugated
Product Specifications
Background
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Synonyms
MAPT; Microtuble-associted protein Tau; AI413597; AW045860; DDPAC; Disinhibition dementia parkinsonism amyotrophy complex; FLJ31424; FTDP 17; FTDP17; G Protein beta 1 gamma 2 subunit interacting factor 1; G protein beta1/gamma2 subunit interacting factor 1; MAPTL; MGC134287; MGC138549; MGC156663; MSTD; Mtapt; MTBT1; MTBT2; Neurofibrillary tangle protein; Paired helical filament tau; PHF tau; PHF-tau; PPND; pTau; RNPTAU; Tauopathy and respiratory failure, included; 0N3R; Isoform Fetal-tau; TAU_HUMAN.
Gene ID
4137
Swiss Prot
P10636-2
Cellular Locus
Cytoplasm, Cell membrane
Host
Mouse
Cross Reactivity
Human
Target
Tau isoform 4
Clonality
Monoclonal
Isotype
IgG
Clone
3E2
Conjugation
APC
Source
Recombinant Tau isoform 4 protein
Applications
WB, IF (IHC-P), IF (IHC-F)
Purification
Purified by Protein A.
Excitation Emission
650nm/660nm
Concentration
1mg/ml
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
4137
Curated Selection
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