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P53 (Mono Methyl Lys370) Monoclonal Antibody, Cy3 Conjugated

Product Specifications

Background

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277) . [provided by RefSeq, Feb 2013].

Synonyms

P53 (Mono Methyl K370) ; p53 (Mono Methyl Lys370) ; Mono Methyl-p53 (Lys370) ; Mono Methyl p53 (K370) ; Widespread p53; Wtp53; Antigen NY-CO-13; Cellular tumor antigen p53; Cys 51 Stop; HGNC11998; LFS1; p53; p53 Cellular Tumor Antigen; p53 Tumor Suppressor; Phosphoprotein p53; TP53; Transformation related protein 53; TRP53; Tumor protein p53; Tumour Protein p53; P53_HUMAN; TP53.

Gene ID

7157

Swiss Prot

P04637

Cellular Locus

Cytoplasm, Nucleus

Host

Mouse

Cross Reactivity

Human, Mouse, Rat

Target

P53 (Mono Methyl Lys370)

Clonality

Monoclonal

Isotype

IgG

Clone

5B10

Conjugation

Cy3

Source

KLH conjugated synthesised methylpeptide derived from human P53 around the methylation site of Mono Methyl Lys370

Applications

WB, IF (ICC), IF

Purification

Purified by Protein G.

Excitation Emission

512,550nm/570,615nm

Concentration

1µg/µl

Dilution

WB (1:300-5000), IF (ICC) (1:50-200), IF ()

Buffer

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

7157

Curated Selection

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