CBARA1/MICU1 Monoclonal Antibody, RBITC Conjugated
Product Specifications
Background
Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988) . MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221) . Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221) . Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221) . Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319) . Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733) .
Synonyms
Mitochondrial Calcium Uptake 1; Calcium-Binding Atopy-Related Autoantigen 1; Atopy-Related Autoantigen CALC; Ara CALC; CBARA1; CALC; Calcium Binding Atopy-Related Autoantigen 1; Calcium Uptake Protein 1, Mitochondrial; Allergen Hom S 4; EFHA3; MPXPS; MICU1_HUMAN
Gene ID
10367
Swiss Prot
Q9BPX6
Cellular Locus
Cytoplasm
Host
Mouse
Cross Reactivity
Human
Target
CBARA1/MICU1
Clonality
Monoclonal
Isotype
IgG
Clone
1H8
Conjugation
RBITC
Source
Recombinant human CBARA1 Protein (1-250/476)
Applications
WB
Purification
Purified by Protein G.
Excitation Emission
570nm/595nm
Concentration
1µg/µl
Dilution
WB (1:300-5000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
10367
Predicted Cross Reactivity
Mouse, Rat
Curated Selection
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