Fibronectin/FN1 Monoclonal Antibody, AbBy Fluor™ 488 Conjugated
Product Specifications
Background
Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts. Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.
Synonyms
Fibronectin; FN1; Cold-insoluble globulin; CIG
Gene ID
2335
Swiss Prot
P02751
Host
Mouse
Cross Reactivity
Human
Target
Fibronectin/FN1
Clonality
Monoclonal
Isotype
IgG
Clone
1B9
Conjugation
AbBy Fluor™ 488
Source
KLH conjugated synthetic peptide derived from human Fibronectin
Applications
WB, IF (IHC-P)
Purification
Purified by Protein G.
Excitation Emission
499nm/519nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
2335
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