Morphine (2F11) Monoclonal Antibody
Product Specifications
Background
Morphine is thought to produce reinforcement phenomena via stimulation of mu, delta, and kappa opioid receptors that regulate stress perception, pain control, reward behavior, and neurohormone secretion in reward-relevant brain systems. It has the highest affinity for mu, followed by delta and kappa. Rapid activation of the mu opioid receptor by morphine results in a euphoric phenotype, thus conferring the reinforcing effects of the drug. This activation is accompanied by extracellular dopamine release, which alters several events related to the cAMP signal transduction pathway. Of particular significance is that CREB seems to be modified by morphine, thereby affecting addictive behavioral phenomena, such as withdrawal symptoms.
Synonyms
Morphine 6.
Host
Mouse
Cross Reactivity
Others
Target
Morphine
Clonality
Monoclonal
Isotype
IgG
Clone
2F11
Conjugation
Unconjugated
Source
KLH conjugated Morphine molecular modified
Applications
WB, ELISA, IHC-P, IHC-F, IF
Purification
Purified by Protein G.
Concentration
1µg/µl
Dilution
WB (WB=1:500-2000), ELISA (ELISA=1:5000-10000), IHC-P (IHC-P=1:100-500), IHC-F (IHC-F=1:100-500), IF (IF=1:100-500)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Cross Reactivity Details
Morphine
Curated Selection
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