Methamphetamine (4D2) Monoclonal Antibody, HRP Conjugated
Product Specifications
Background
Methamphetamine (METH) is closely related chemically to amphetamine (AMPH) . METH is a potent central nervous system stimulant with additional peripheral sympathomimetic effects. METH and AMPH have been used clinically in the treatment of obesity, minimal brain dysfunction, narcolepsy, depression and to counter fatigue. They are also subjected to widespread abuse. METH is an indirect agonists. It causes the release of newly synthesized norepinephrine and dopamine and it blocks the re uptake of these transmitters from the synapse. This can lead to an increase in the concentration of catecholamines in the synapse as well as an overall increase in catecholaminergic activity in the brain. The mechanism of METH induced neurotoxicity for all monoaminergic cell types may lie primarily with the dopaminergic system in the striatum. It may also lie with the interaction between METH induced release of dopamine and its ability to inhibit monoamine oxidase.
Synonyms
D-Desoxyephedrine hydrochloride; d-N; -Dimethylphenethylamine hydrochloride; Methylamphetamine hydrochloride; METH.
Host
Mouse
Cross Reactivity
Others
Target
Methamphetamine
Clonality
Monoclonal
Isotype
IgG
Clone
4D2
Conjugation
HRP
Source
KLH conjugated Methamphetamine
Applications
ELISA
Purification
Purified by Protein G.
Concentration
1µg/µl
Dilution
ELISA (1:500-1000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Cross Reactivity Details
Methamphetamine
Curated Selection
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