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Photoclick cholesterol

Photoclick cholesterol is a sterol lipid cholesterol analog that contains a clickable terminal alkyne moiety and a photoactivatable diaziridine group. Photoclick cholesterol has the ability to photoaffinity label the mitochondrial outer membrane transport protein (TSPO) and is able to specifically bind cholesterol to TSPO. However, using excessive amounts of Photoclick cholesterol will reduce the photolabeling of total mitochondrial proteins and TSPO[1].

Product Specifications

CAS Number

[1485490-47-8]

UNSPSC

12352005

Target

Biochemical Assay Reagents

Type

Reference compound

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/photoclick-cholesterol.html

Smiles

C[C@]12[C@@](C[C@H](CC2)O)([H])C3(N=N3)C[C@]4([H])[C@]1([H])CC[C@]5([C@@]4([H])CC[C@]5([H])[C@H](C)CCC(OCCCCC#C)=O)C

Molecular Formula

C30H46N2O3

Molecular Weight

482.70

References & Citations

[1]Georges E, et al. Direct and specific binding of cholesterol to the mitochondrial translocator protein (TSPO) using PhotoClick cholesterol analogue[J]. The journal of biochemistry, 2021, 170 (2) : 239-243.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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