Bcl-2 Monoclonal Antibody, Cy7 Conjugated

Product Specifications

Background

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) . May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release

Synonyms

Apoptosis regulator Bcl-2; BCL2

Gene ID

596

Swiss Prot

P10415

Host

Mouse

Cross Reactivity

Human

Target

Bcl-2

Clonality

Monoclonal

Isotype

IgG

Clone

1A5

Conjugation

Cy7

Source

Recombinant protein fragment (1-220 amino acids range) of human Bcl-2.

Applications

Purification

Purified by Protein G.

Excitation Emission

743nm/767nm

Concentration

1µg/µl

Dilution

WB (1:300-5000)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

596

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