Bcl-2 Monoclonal Antibody, AbBy Fluor™ 488 Conjugated
Product Specifications
Background
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) . May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release
Synonyms
Apoptosis regulator Bcl-2; BCL2
Gene ID
596
Swiss Prot
P10415
Host
Mouse
Cross Reactivity
Human
Target
Bcl-2
Clonality
Monoclonal
Isotype
IgG
Clone
1A5
Conjugation
AbBy Fluor™ 488
Source
Recombinant protein fragment (1-220 amino acids range) of human Bcl-2.
Applications
WB
Purification
Purified by Protein G.
Excitation Emission
499nm/519nm
Concentration
1µg/µl
Dilution
WB (1:300-5000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
596
Curated Selection
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