Deltarasin (trihydrochloride)

Deltarasin is an inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ. Deltarasin can be used in the study of cancer.

Product Specifications

CAS Number

[1440898-82-7]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Phosphodiesterase (PDE) ; Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/deltarasin-trihydrochloride.html

Solubility

10 mM in DMSO

Smiles

C1(CN2C3=CC=CC=C3N=C2C4=CC=C(OC[C@@H](N5C6=CC=CC=C6N=C5C7=CC=CC=C7)C8CCNCC8)C=C4)=CC=CC=C1.Cl.Cl.Cl

Molecular Formula

C40H40Cl3N5O

Molecular Weight

713.14

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Zimmermann G, et al. Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. Nature. 2013 May 30;497 (7451) :638-42.|[2]Agalioti T, et al. Mutant KRAS promotes malignant pleural effusion formation. Nat Commun. 2017 May 16;8:15205. doi: 10.1038/ncomms15205.