PDE4A8 Polyclonal Antibody, Cy5 Conjugated
Product Specifications
Background
The PDE4A8 is a testis germ cell-specific PDE4A variant. There are two PDE4A variants identified in rat testis (PDE4A8 and an un-characterized 76 kDa PDE4A protein) . Spermatogenesis is accompanied by expression of a varied repertoire of PDE4 enzymes at different stages of cell differentiation that presumably perform specialized functions. Confocal microscopic examination revealed the presence of PDE4A8 in primary and secondary spermatids but not in mature spermatozoa. PDE4A8 inhibition results in increased apoptosis of the germ cells accompanied with reduction in the number of mature spermatozoa.
Synonyms
2EL; DPDE2; PDE4; PDE46; PDE4A; Phosphodiesterase 4A; Phosphodiesterse Type 4A8; PDE4A_HUMAN.
Gene ID
5141
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Immunogen
201-300/886
Target
PDE4A8
Clonality
Polyclonal
Isotype
IgG
Conjugation
Cy5
Source
KLH conjugated synthetic peptide derived from human PDE4A8
Applications
WB, IF (IHC-P)
Purification
Purified by Protein A.
Excitation Emission
625,650nm/670nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
5141
Curated Selection
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