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Copine-6 Polyclonal Antibody, Cy3 Conjugated

Product Specifications

Background

Copine 6 is a 557 amino acid member of the copine family of evolutionarily conserved, soluble, calcium-dependent, membrane-binding proteins. Members of the copine family are involved in signal transduction and membrane trafficking. Arabidopsis thaliana mutants lacking copine proteins exhibit reduced cell number and smaller cell size, effects which may be due to a defect in vesicle fusion or transport. Copine 6 contains two N-terminal C2 domains and one C-terminal VWFA (von Willebrand factor A) domain, which is also referred to as the A domain or the core domain. As is characteristic of the copine family, copine 6 functions in membrane trafficking and is capable of binding phospholipids in a calcium-dependent manner. Copine 6 may also play a role in synaptic plasticity.

Synonyms

Copine 6; Copine VI neuronal; Copine VI; Copine-6; Copine6; CopineVI; CPNE 6; Cpne6; CPNE6_HUMAN; N copine; N-copine; Neuronal copine; Neuronal-copine.

Host

Rabbit

Cross Reactivity

Human

Immunogen

221-320/557

Target

Copine-6

Clonality

Polyclonal

Isotype

IgG

Conjugation

Cy3

Source

KLH conjugated synthetic peptide derived from human Copine-6

Applications

WB, IF (IHC-P)

Purification

Purified by Protein A.

Excitation Emission

512,550nm/570,615nm

Concentration

1µg/µl

Dilution

WB (1:300-5000), IF (IHC-P) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Predicted Cross Reactivity

Mouse, Rat, Sheep, Pig, Horse, Rabbit

Curated Selection

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