Orai2 Polyclonal Antibody, APC-Cy5.5 Conjugated

Orai2 is a 254 amino acid multi-pass membrane protein that belongs to the orai family of proteins. Localizing to the plasma membrane, Orai2 plays an important role in store-operated calcium (SOC) entry, a process involving Ca2+ influx and replenishment of Ca2+ stores formerly emptied through the action of inositol 1,4,5-trisphosphate production and other Ca2+ mobilizing agents. CRAC channels are responsible for medi-ating calcium influx in T-cells and play an important role in the immune response. Orai2 specifically increases the Ca2+-selective current through coaction with the Ca2+ sensor Stim1.

C7orf19; CAP binding protein complex interacting protein 2; CBCIP 2; CBCIP2; Chromosome 7 open reading frame 19; FLJ12474; FLJ14733; FLJ44818; H_NH0514P08.8; Orai 2; ORAI calcium release activated calcium modulator 2; Protein orai 2; TMEM 142B; TMEM142B; Transmembrane protein 142B.