RNF59/MID1 Polyclonal Antibody, PE Conjugated

Midline-1 (Tripartite motif-containing protein 18, Putative transcription factor XPRF, RING finger protein 59) is a 667 amino acid protein encoded by the human gene MID1. Midline-1 belongs to the TRIM/RBCC family and contains two B box-type zinc fingers, one B30.2/SPRY domain, one COS domain, one fibronectin type-III domain and one RING-type zinc finger. Midline-1 is believed to have E3 ubiquitin ligase activity which targets the catalytic subunit of protein phosphatase 2 for degradation. It is a cytoplasmic protein found as a homodimer or heterodimer with Midline-2. It also interacts with IGBP1 (Lymphocyte signaling protein A4) . Defects in MID1 are the cause of Opitz syndrome type I (OS-I) . OS-I is an X-linked recessive disorder characterized by hypertelorism, genital-urinary defects such as hypospadias in males and splayed labia in females, lip-palate-laryngotracheal clefts, imperforate anus, developmental delay and congenital heart defects. OS-I mutations produce proteins with a decreased affinity for microtubules.

BBBG1; Finger on X and Y mouse homolog of antibody; FXY; GBBB1; MID-1; Mid1; Midin; Midline 1 Opitz/BBB syndrome; Midline 1; Midline 1 ring finger; Midline 1 RING finger protein; Midline-1; Midline1; OGS1; OSX; Putative transcription factor XPRF; RING finger protein 59; RNF59; TRI18; TRI18_HUMAN; TRIM18; Tripartite mot containing protein 18; Tripartite mot protein TRIM18; Tripartite mot-containing protein 18; XPRF; Zinc finger X and Y antibody; ZNFXY.