CA IX/VEGFR-2-IN-2
Product Specifications
UNSPSC Description
CA IX/VEGFR-2-IN-2 (compound 5e) is a dual-targeted inhibitor. CA IX/VEGFR-2-IN-2 shows strong inhibitory effects on both CA IX (Ki=3.1 μM) and VEGFR-2 (IC50=32.1 nM). CA IX/VEGFR-2-IN-2 can be used for the study of pancreatic (PANC1), breast cancer (MCF7) and prostate cancer (PC3) [1].
Target Antigen
Bcl-2 Family; Carbonic Anhydrase; Caspase; Cytochrome P450; MDM-2/p53; Reactive Oxygen Species; VEGFR
Type
Reference compound
Related Pathways
Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ca-ix-vegfr-2-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C1C(/C(C)=N/NC2=NC(C3=CC=C(F)C=C3)=CS2)=CC4=C(O1)C(OCC)=CC=C4
Molecular Weight
423.46
References & Citations
[1]Hefny S M, et al. Discovery and Mechanistic Studies of Dual-Target Hits for Carbonic Anhydrase IX and VEGFR-2 as Potential Agents for Solid Tumors: X-ray, In Vitro, In Vivo, and In Silico Investigations of Coumarin-Based Thiazoles[J]. Journal of Medicinal Chemistry, 2024.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-158328A/CA-IX-VEGFR-2-IN-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-158328A/
Clinical Information
No Development Reported
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