CA IX/VEGFR-2-IN-2

CA IX/VEGFR-2-IN-2 (compound 5e) is a dual-targeted inhibitor. CA IX/VEGFR-2-IN-2 shows strong inhibitory effects on both CA IX (Ki=3.1 μM) and VEGFR-2 (IC50=32.1 nM) . CA IX/VEGFR-2-IN-2 can be used for the study of pancreatic (PANC1), breast cancer (MCF7) and prostate cancer (PC3) [1].

Product Specifications

UNSPSC

12352005

Target

Bcl-2 Family; Carbonic Anhydrase; Caspase; Cytochrome P450; MDM-2/p53; Reactive Oxygen Species (ROS) ; VEGFR

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ca-ix-vegfr-2-in-2.html

Solubility

10 mM in DMSO

Smiles

O=C1C(/C(C)=N/NC2=NC(C3=CC=C(F)C=C3)=CS2)=CC4=C(O1)C(OCC)=CC=C4

Molecular Formula

C22H18FN3O3S

Molecular Weight

423.46

References & Citations

[1]Hefny S M, et al. Discovery and Mechanistic Studies of Dual-Target Hits for Carbonic Anhydrase IX and VEGFR-2 as Potential Agents for Solid Tumors: X-ray, In Vitro, In Vivo, and In Silico Investigations of Coumarin-Based Thiazoles[J]. Journal of Medicinal Chemistry, 2024.