(6S) -CP-470711

(6S) -CP-470711 (Compound 8) is an inhibitor for sorbitol dehydrogenase, that inhibits human and rat SDH with IC50 of 19 nM and 27 nM. (6S) -CP-470711 ameliorates the Streptozotocin (HY-13753) -induced diabetes in rats models[1].

Product Specifications

CAS Number

[300552-09-4]

UNSPSC

12352005

Target

Aldehyde Dehydrogenase (ALDH)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/6s-cp-470711.html

Purity

98.75

Solubility

DMSO : 2 mg/mL (ultrasonic; warming; adjust pH to 6 with 1 M HCl; heat to 60°C)

Smiles

C[C@@H]1N(C2=NC([C@@H](O)C)=NC=C2)[C@@H](CN(C3=NC([C@H](O)C)=NC=C3)C1)C

Molecular Formula

C18H26N6O2

Molecular Weight

358.44

References & Citations

[1]Chu-Moyer MY, et al., SAR and species/stereo-selective metabolism of the sorbitol dehydrogenase inhibitor, CP-470,711. Bioorg Med Chem Lett. 2002 Jun 3;12 (11) :1477-80.