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(S) -Elobixibat

(S) -Elobixibat is the S enantiomer of Elobixibat. (S) -Elobixibat is an orally effective Apical Sodium-Dependent Bile (IBAT) inhibitor. (S) -Elobixibat decreases LDL cholesterol, increases serum GLP-1, promotes colon motility, and has the potential to treat metabolic syndrome. (S) -Elobixibat can be used to study constipation, dyslipidemia, non-alcoholic hepatitis, and liver tumors[1][2][3].

Product Specifications

CAS Number

439087-68-0

Product Name Alternative

(S) -A 3309; (S) -AZD 7806

UNSPSC

12352005

Target

Apical Sodium-Dependent Bile Acid Transporter; Interleukin Related; TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/s-elobixibat.html

Purity

99.53

Smiles

O=C(O)CNC([C@H](C1=CC=CC=C1)NC(COC2=C(SC)C=C(C3=C2)N(C4=CC=CC=C4)CC(CCCC)(CCCC)CS3(=O)=O)=O)=O

Molecular Formula

C36H45N3O7S2

Molecular Weight

695.89

References & Citations

[1]Wong BS, et al. Elobixibat for the treatment of constipation. Expert Opin Investig Drugs. 2013 Feb; 22 (2) :277-84.|[2]Sugiyama Y, et al. Impact of elobixibat on liver tumors, microbiome, and bile acid levels in a mouse model of nonalcoholic steatohepatitis. Hepatol Int. 2023 Dec;17 (6) :1378-1392. |[3]Yamauchi R, et al. Elobixibat, an ileal bile acid transporter inhibitor, ameliorates non-alcoholic steatohepatitis in mice. Hepatol Int. 2021 Apr;15 (2) :392-404.

Shipping Conditions

Room Temperature

Storage Conditions

RT, protect from light

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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