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Mecbotamab vedotin

Mecbotamab vedotin (BA3011) is a pH dependent antibody drug conjugate (ADC) targeting AXL. Mecbotamab vedotin can significantly inhibit AXL in DU145 cells and LCLC-103H cells and kills cells. Mecbotamab vedotin can be used for research on cancer such as lung cancer, pancreatic cancer and prostate cancer. The antibody component is Mecbotamab , and the ADC toxin molecule is Vedotin (HY-15162).

Product Specifications

CAS Number

2460400-64-8

Product Name Alternative

BA3011; CAB-Axl-ADC; CAB-anti-Axl-ADC

UNSPSC

12352100

Target

Antibody-Drug Conjugates (ADCs) ; TAM Receptor

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mecbotamab-vedotin.html

Purity

99.11

Solubility

10 mM in DMSO

Smiles

[Mecbotamabvedotin]

References & Citations

[1]Chang HW, et al. Preclinical development of mecbotamab vedotin (BA3011), a novel, AXL-specific conditional active biologic antibody-drug conjugate. Antib Ther. 2025 Apr 10;8 (2) :145-156.

Shipping Conditions

Dry Ice

Storage Conditions

-80°C, protect from light

Scientific Category

Reference compound1

Clinical Information

Phase 2

Available Sizes

Frequently Asked Questions

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