ZNRF3 Polyclonal Antibody

Product Specifications

Background

E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.

Synonyms

RNF203; BK747E2.3; E3 ubiquitin-protein ligase ZNRF3; RING finger protein 203; Zinc/RING finger protein 3; ZNRF3; KIAA1133

Gene ID

84133

Swiss Prot

Q9ULT6

Cellular Locus

Extracellular

Host

Rabbit

Cross Reactivity

Human, Mouse, Rat

Immunogen

101-200/936

Target

ZNRF3

Clonality

Polyclonal

Isotype

IgG

Conjugation

Unconjugated

Source

KLH conjugated synthetic peptide derived from human ZNRF3

Applications

WB, IHC-P, IHC-F, IF

Purification

Purified by Protein A.

Concentration

1µg/µl

Dilution

WB (WB=1:500-2000), IHC-P (IHC-P=1:100-500), IHC-F (IHC-F=1:100-500), IF (IF=1:50-200)

Buffer

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Gene ID URL

84133

Available Sizes

Curated Selection

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