COPS4 Polyclonal Antibody
Product Specifications
Background
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Synonyms
CH4; COP9 constitutive photomorphogenic homolog subunit 4; COP9 complex homolog subunit 4; COP9 complex S4; COP9 constitutive photomorphogenic homolog subunit 4; COP9 signalosome complex subunit 4; COP9 signalosome subunit 4; COPS4; CSN complex subunit 4; CSN4; CSN4 SCHPO; CSN4_HUMAN; DCH4; JAB1 containing signalosome subunit 4; JAB1-containing signalosome subunit 4; MGC94896; SGN4; Signalosome subunit 4.
Gene ID
51138
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Immunogen
101-220/406
Target
COPS4
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human COPS4
Applications
WB, IHC-P, IF (IHC-P)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), IHC-P (1:200-400), IF (IHC-P) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
51138
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