COPS6 Polyclonal Antibody, Cy3 Conjugated
Product Specifications
Background
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity.
Synonyms
JAB1 containing signalosome subunit 6; COP9 subunit 6 MOV34 homolog, 34 kD; MOV34 homolog, 34 kD; COP9 constitutive photomorphogenic, subunit 6; COP9 complex S6; COP9 signalosome complex subunit 6; COP9 signalosome subunit 6; cops6; CSN6; CSN6_HUMAN; hVIP; JAB1-containing signalosome subunit 6; MOV34 homolog; MOV34-34KD; Sgn3; SGN6; Signalosome subunit 6; VIP/MOV34; Vpr interacting protein; Vpr-interacting protein.
Gene ID
10980
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Immunogen
101-250/327
Target
COPS6
Clonality
Polyclonal
Isotype
IgG
Conjugation
Cy3
Source
KLH conjugated synthetic peptide derived from human COPS6
Applications
IF
Purification
Purified by Protein A.
Excitation Emission
512,550nm/570,615nm
Concentration
1µg/µl
Dilution
IF (IF=1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.biossantibodies.com/datasheets/bs-9120R-Cy3
Gene ID URL
10980
Curated Selection
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