FBXW5 Polyclonal Antibody, APC-Cy7 Conjugated
Product Specifications
Background
FBXW5 is a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. FBXW5 contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented.
Synonyms
F box and WD 40 domain containing protein 5; F box and WD repeat domain containing 5; FBW5; FBXW5_HUMAN.
Gene ID
54461
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Immunogen
201-300/566
Target
FBXW5
Clonality
Polyclonal
Isotype
IgG
Conjugation
APC-Cy7
Source
KLH conjugated synthetic peptide derived from human FBXW5
Applications
WB, IF (IHC-P)
Purification
Purified by Protein A.
Excitation Emission
650nm/780nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
54461
Curated Selection
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