Phospho-Dishevelled 2 (Thr224) Polyclonal Antibody, Cy5 Conjugated
Product Specifications
Background
Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity) .
Synonyms
Segment polarity protein dishevelled homolog DVL-2; Dishevelled-2; DSH homolog 2; DVL2
Gene ID
1856
Swiss Prot
O14641
Modification Site
Thr224
Cellular Locus
Cytoplasm
Host
Rabbit
Cross Reactivity
Human
Target
Phospho-Dishevelled 2 (Thr224)
Clonality
Polyclonal
Isotype
IgG
Conjugation
Cy5
Source
KLH conjugated synthetic phosphopeptide derived from human DVL2 around the phosphorylation site of Thr224
Applications
WB, IF (IHC-P)
Purification
Purified by Protein A.
Excitation Emission
625,650nm/670nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Specificity
This antibody will recognize DVL3 when phosphorylated at Thr205
Gene ID URL
1856
Predicted Cross Reactivity
Mouse, Rat, Dog, Cow, Sheep, Pig, Horse, Chicken
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