DHFR Polyclonal Antibody, HRP Conjugated
Product Specifications
Background
DHFR catalyzes the NADPH-dependent reduction of dihydrofolate to tetrahydrofolate, and is a crucial enzyme for the synthesis of purines, pyrimidines and some amino acids. Inhibition of the activity of this enzyme leads to arrest of DNA synthesis and cell death. Gene expression of methotrexate (MTX) -resistant variants of DHFR in normal hematopoietic cells is a potential strategy to permit administration of larger doses of MTX by alleviating drug toxicity in normal cells and tissues that are drug sensitive.
Synonyms
DHFR; DHFRP1; Dihydrofolate reductase; DYR; DYR_HUMAN; EC 1.5.1.3.
Gene ID
1719
Swiss Prot
P00374
Cellular Locus
Cytoplasm
Host
Rabbit
Cross Reactivity
Human, Mouse
Immunogen
51-150/189
Target
DHFR
Clonality
Polyclonal
Isotype
IgG
Conjugation
HRP
Source
KLH conjugated synthetic peptide derived from human DHFR
Applications
IHC-P, IHC-F
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
IHC-P (IHC-P=1:100-500), IHC-F (IHC-F=1:100-500)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
1719
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