Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

HA15

HA15 is a potent and specific inhibitor of ER chaperone BiP/GRP78/HSPA5, inhibits the ATPase activity of BiP, with anti-cancerous activity[1].

Product Specifications

CAS Number

[1609402-14-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; HSP

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/HA15.html

Purity

99.98

Solubility

DMSO : ≥ 50 mg/mL

Smiles

CC(NC1=NC(C2=CC=CC(NS(=O)(C3=C4C=CC=C(N(C)C)C4=CC=C3)=O)=C2)=CS1)=O

Molecular Formula

C23H22N4O3S2

Molecular Weight

466.58

Precautions

H302, H315, H319, H335

References & Citations

[1]Cerezo M et al. Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance. Cancer Cell. 2016 Jun 13;29 (6) :805-19.|[2]Ruggiero C, et al. The GRP78/BiP inhibitor HA15 synergizes with mitotane action against adrenocortical carcinoma cells through convergent activation of ER stress pathways. Mol Cell Endocrinol. 2018 Oct 15;474:57-64.|[3]Duo Xu, et al. Endoplasmic Reticulum Stress Signaling as a Therapeutic Target in Malignant Pleural Mesothelioma. Cancers (Basel) . 2019 Oct; 11 (10) : 1502.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

HSP70

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

HTRA2 (NM_145074) Human Over-expression Lysate
LS027429-100ug 100 µg

HTRA2 (NM_145074) Human Over-expression Lysate

Ask
View Details
Olfr1262 (NM_146974) Mouse Tagged ORF Clone Lentiviral Particle
MR213842L3V 200 µL

Olfr1262 (NM_146974) Mouse Tagged ORF Clone Lentiviral Particle

Ask
View Details
LYSMD1 Rabbit Polyclonal Antibody
TA335114 100 µL

LYSMD1 Rabbit Polyclonal Antibody

Ask
View Details
Anti-Mouse MHC Class I In Vivo Antibody - Low Endotoxin (A4C8.1-Do9)
MBS3030109-01 5 mg

Anti-Mouse MHC Class I In Vivo Antibody - Low Endotoxin (A4C8.1-Do9)

Ask
View Details
Anti-Mouse MHC Class I In Vivo Antibody - Low Endotoxin (A4C8.1-Do9)
MBS3030109-02 25 mg

Anti-Mouse MHC Class I In Vivo Antibody - Low Endotoxin (A4C8.1-Do9)

Ask
View Details
Anti-Mouse MHC Class I In Vivo Antibody - Low Endotoxin (A4C8.1-Do9)
MBS3030109-03 50 mg

Anti-Mouse MHC Class I In Vivo Antibody - Low Endotoxin (A4C8.1-Do9)

Ask
View Details