ORC1L/ORC1 Polyclonal Antibody, APC-Cy5.5 Conjugated

The initiation of DNA replication is a multi-step process that depends on the formation of pre-replication complexes, which trigger initiation (1) . Among the proteins required for establishing these complexes are the origin recognition complex (ORC) proteins (1) . ORC proteins bind specifically to origins of replication where they serve as scaffold for the assembly of additional initiation factors (1) . Human ORC subunits 1-6 are expressed in the nucleus of proliferating cells and tissues, such as the testis (2) . ORC1 and ORC2 are both expressed at equivalent concentrations throughout the cell cycle; however, only ORC2 remains stably bound to chromatin (3,4) . ORC4 and ORC6 are also expressed constantly throughout the cell cycle (5,6) . ORC2, ORC3, ORC4 and ORC5 form a core complex upon which ORC6 and ORC1 assemble (7,8) . The formation of this core complex suggests that ORC proteins play a crucial role in the G1-S transition in mammalian cells (8) .

HSORC1; MmORC1; orc1; ORC1_HUMAN; ORC1L; Origin Recognition Complex 1; Origin recognition complex subunit 1 yeast homolog like; Origin recognition complex subunit 1; Origin recognition complex subunit 1 homolog; Origin recognition complex subunit 1 like S. cerevisia; Origin recognition complex subunit 1 like; Origin recognition complex subunit 1 S. cerevisiae homolog like; Origin recognition complex, subunit 1 like yeast; PARC1; Replication control protein 1.