SMAD8/SMAD9 Polyclonal Antibody, APC Conjugated
Product Specifications
Background
Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway
Synonyms
AI528653 ; BSP 1 ; BSP1 ; DKFZp781C1895 ; DKFZp781O1323 ; Dwarfin A ; Dwf A ; DwfA ; Dwfc ; hSMAD1 ; hSmad5 ; JV 41 ; JV4 1 ; JV41 ; JV5 1 ; MAD (mothers against decapentaplegic, Drosophila) homolog 1 ; MAD (mothers against decapentaplegic, Drosophila) homolog 9 ; MAD homolog 1 ; MAD homolog 9 ; MAD homolog1 (mothers against decapentaplegic, Drosophila)
Gene ID
142891
Swiss Prot
Q96LT4
Cellular Locus
Cytoplasm, Nucleus
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Immunogen
351-450/467
Target
SMAD8/SMAD9
Clonality
Polyclonal
Isotype
IgG
Conjugation
APC
Source
KLH conjugated synthetic peptide derived from human SMAD8
Applications
IF (IHC-P), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
650nm/660nm
Concentration
1µg/µl
Dilution
IF (IHC-P) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
142891
Predicted Cross Reactivity
Zebrafish
Curated Selection
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