Phospho-IRS1 (Tyr1179) Polyclonal Antibody, APC-Cy7 Conjugated
Product Specifications
Background
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.
Synonyms
IRS1 (phospho S1179) ; p-IRS1 (phospho S1179) ; p-IRS1; IRS1 (phospho-Ser1179) ; HIRS 1; HIRS1; Insulin Receptor Substrate 1; IRS-1; IRS 1; IRS1; OTTHUMP00000164234; IRS1_HUMAN.
Gene ID
3667
Swiss Prot
P35568
Modification Site
Tyr1179
Cellular Locus
Cell membrane
Host
Rabbit
Cross Reactivity
Human, Mouse, Zebrafish
Target
Phospho-IRS1 (Tyr1179)
Clonality
Polyclonal
Isotype
IgG
Conjugation
APC-Cy7
Source
KLH conjugated synthesised phosphopeptide derived from human IRS1 around the phosphorylation site of Ser1179.
Applications
FCM, IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
650nm/780nm
Concentration
1µg/µl
Dilution
FCM (1:20-100), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
3667
Predicted Cross Reactivity
Rat, Dog, Cow, Sheep, Pig, Chicken, Rabbit, GuineaPig
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