Connexin-29 Polyclonal Antibody
Product Specifications
Background
Connexin 29 belongs to the connexin family and is a member of the epsilon-type subfamily. Connexin 29 is a membrane bound, multi-pass protein also known as gap junction epsilon-1 protein. A connexon, consisting of connexin hexamers, is a membrane bound structure that is integral in the formation of a gap junction. One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low molecular weight diffuse from one cell to a neighboring cell. Connexin 29 expression is restricted to the central nervous system and is present in brain, spinal cord, and sciatic nerve samples. It has been suggested that connexin 29 in the mature CNS contributes minimally to gap junctional intercellular communication in oligodendrocyte cell bodies. Rather, connexin 29 is targeted to myelin where it, along with connexin 32, may contribute to connexin-mediated communication between adjacent layers of uncompacted myelin.
Synonyms
Connexin 29; connexin29; connexin-29; Connexin 30.2; Connexin 31.3; Connexin-30.2; Connexin-31.3; CX23; Cx29 ; Cx30.2; Cx31.3; CXG3_HUMAN; Gap junction epsilon 1 protein; Gap junction epsilon-1 protein ; Gap junction gamma 3 protein; Gap junction gamma-3 protein; Gap junction protein epsilon 1 29kDa; Gap junction protein epsilon 1; Gap junction protein gamma 3 30.2kDa; Gap junction protein gamma 3; GJC 3 antibodyGJC3; GJE 1.
Cellular Locus
Cell membrane
Host
Rabbit
Immunogen
71-170/269
Target
Connexin-29
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from mouse Connexin 29
Applications
WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Predicted Cross Reactivity
Mouse, Rat
Curated Selection
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