Phospho-ZIP Kinase (Thr265) Polyclonal Antibody, Cy3 Conjugated

Product Specifications

Background

Serine/threonine kinase which acts as a positive regulator of apoptosis. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. Regulates myosin light chain phosphatase through phosphorylation of MYPT1 thereby regulating the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. Involved in the formation of promyelocytic leukemia protein nuclear body (PML-NB), one of many subnuclear domains in the eukaryotic cell nucleus, and which is involved in oncogenesis and viral infection.

Synonyms

Death-associated protein kinase 3; DAPK3; DAP kinase 3; Dlk; MYPT1 kinase; Zipper-interacting protein kinase; ZIP-kinase; ZIPK

Gene ID

1613

Swiss Prot

O43293

Modification Site

Thr265

Cellular Locus

Cytoplasm, Nucleus

Host

Rabbit

Cross Reactivity

Mouse, Rat

Target

Phospho-ZIP Kinase (Thr265)

Clonality

Polyclonal

Isotype

IgG

Conjugation

Cy3

Source

KLH conjugated synthesised phosphopeptide derived from human ZIP Kinase around the phosphorylation site of Thr265

Applications

WB, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

512,550nm/570,615nm

Concentration

1µg/µl

Dilution

WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

1613

Predicted Cross Reactivity

Human, Dog, Cow, Pig, Horse

Curated Selection

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