Phospho-ZIP Kinase (Thr265) Polyclonal Antibody, Biotin Conjugated
Product Specifications
Background
Serine/threonine kinase which acts as a positive regulator of apoptosis. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. Regulates myosin light chain phosphatase through phosphorylation of MYPT1 thereby regulating the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. Involved in the formation of promyelocytic leukemia protein nuclear body (PML-NB), one of many subnuclear domains in the eukaryotic cell nucleus, and which is involved in oncogenesis and viral infection.
Synonyms
Death-associated protein kinase 3; DAPK3; DAP kinase 3; Dlk; MYPT1 kinase; Zipper-interacting protein kinase; ZIP-kinase; ZIPK
Gene ID
1613
Swiss Prot
O43293
Modification Site
Thr265
Cellular Locus
Cytoplasm, Nucleus
Host
Rabbit
Cross Reactivity
Mouse, Rat
Target
Phospho-ZIP Kinase (Thr265)
Clonality
Polyclonal
Isotype
IgG
Conjugation
Biotin
Source
KLH conjugated synthesised phosphopeptide derived from human ZIP Kinase around the phosphorylation site of Thr265
Applications
WB, ELISA, IHC-P, IHC-F
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
1613
Predicted Cross Reactivity
Human, Dog, Cow, Pig, Horse
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