KDM5-C70

KDM5-C70 is an ethyl ester derivative of KDM5-C49 and a potent, cell-permeable and pan-KDM5 histone demethylase inhibitor. KDM5-C70 has an antiproliferative effect in myeloma cells, leading to genome-wide elevation of H3K4me3 levels[1][2].

Product Specifications

CAS Number

[1596348-32-1]

UNSPSC

12352005

Hazard Statement

H225, H319

Target

Histone Demethylase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/kdm5-c70.html

Purity

98.82

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(CNCC(N(CCN(C)C)CC)=O)=NC=C1)OCC

Molecular Formula

C17H28N4O3

Molecular Weight

336.43

Precautions

H225, H319

References & Citations

[1]Johansson C, et al. Structural analysis of human KDM5B guides histone demethylase inhibitor development. Nat Chem Biol. 2016 Jul;12 (7) :539-45.|[2]Blair LP, et al. KDM5 lysine demethylases are involved in maintenance of 3'UTR length. Sci Adv. 2016 Nov 18;2 (11) :e1501662.