H2AX (Ubiquityl Lys119) Polyclonal Antibody, PE-Cy7 Conjugated
Product Specifications
Background
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Synonyms
H2AX; H2A.X; H2A/X; Histone H2AX; Histone H2A.X; H2AFX
Gene ID
3014
Swiss Prot
P16104
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Human, Rat
Target
H2AX (Ubiquityl Lys119)
Clonality
Polyclonal
Isotype
IgG
Conjugation
PE-Cy7
Source
KLH conjugated synthetic peptide derived from human Ubiquityl Histone H2A.X (Lys119)
Applications
WB
Purification
Purified by Protein A.
Excitation Emission
488nm/780nm
Concentration
1µg/µl
Dilution
WB (1:300-5000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Specificity
This modification site is homologous to that of Lys119 in Rat.
Gene ID URL
3014
Predicted Cross Reactivity
Cow, Pig, Rabbit
Curated Selection
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