MtTF1/TFAM Polyclonal Antibody
Product Specifications
Background
Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.
Synonyms
TCF6; MTTF1; MTTFA; TCF6L1; TCF6L2; TCF6L3; Transcription factor A, mitochondrial; Mitochondrial transcription factor 1; Transcription factor 6; TCF-6; Transcription factor 6-like 2; TFAM
Gene ID
7019
Swiss Prot
Q00059
Cellular Locus
Cytoplasm
Host
Rabbit
Cross Reactivity
Human
Immunogen
155-246/246
Target
MtTF1/TFAM
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human MtTF1
Applications
WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
7019
Predicted Cross Reactivity
Mouse, Rat
Curated Selection
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