FBXO11 Polyclonal Antibody, APC-Cy7 Conjugated
Product Specifications
Background
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF (FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF (FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF (FBXO11) does not seem to direct ubiquitination of p53/TP53.
Synonyms
UBR6; VIT1; FBX11; PRMT9; UG063H01; F-box only protein 11; Protein arginine N-methyltransferase 9; Vitiligo-associated protein 1; VIT-1; FBXO11
Gene ID
80204
Swiss Prot
Q86XK2
Cellular Locus
Nucleus
Host
Rabbit
Immunogen
65-160/927
Target
FBXO11
Clonality
Polyclonal
Isotype
IgG
Conjugation
APC-Cy7
Source
KLH conjugated synthetic peptide derived from human FBXO11
Applications
IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
650nm/780nm
Concentration
1µg/µl
Dilution
IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
80204
Predicted Cross Reactivity
Human, Mouse, Rat, Cow, Sheep, Pig, Horse, Chicken
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS7177996 Inquire
Rabbit anti-Escherichia coli O81 (strain ED1a) IBPB Polyclonal Antibody
Ask
View Details 
