FBXO11 Polyclonal Antibody, APC Conjugated
Product Specifications
Background
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF (FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF (FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF (FBXO11) does not seem to direct ubiquitination of p53/TP53.
Synonyms
UBR6; VIT1; FBX11; PRMT9; UG063H01; F-box only protein 11; Protein arginine N-methyltransferase 9; Vitiligo-associated protein 1; VIT-1; FBXO11
Gene ID
80204
Swiss Prot
Q86XK2
Cellular Locus
Nucleus
Host
Rabbit
Immunogen
65-160/927
Target
FBXO11
Clonality
Polyclonal
Isotype
IgG
Conjugation
APC
Source
KLH conjugated synthetic peptide derived from human FBXO11
Applications
IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
650nm/660nm
Concentration
1µg/µl
Dilution
IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
80204
Predicted Cross Reactivity
Human, Mouse, Rat, Cow, Sheep, Pig, Horse, Chicken
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