Lin28 Polyclonal Antibody, RBITC Conjugated
Product Specifications
Background
LIN-28 is a highly conserved, RNA-binding, cytoplasmic protein. It consists of a cold shock domain and retroviral-type (CCHC) zinc finger motifs that were first identified in Caenorhabditis elegans. LIN-28 controls the timing of events during embryonic development and is readily expressed in embryos, embryonic stem cells and embryonal carcinoma cells. The presence of LIN-28 persists in some adult tissues including cardiac and skeletal muscle. In differentiating myoblasts, LIN-28 increases protein synthesis efficiency and binds to the growth and differentiation factor IGF-II.
Synonyms
Protein lin-28 homolog A; LIN28A; Lin-28A; Zinc finger CCHC domain-containing protein 1; CSDD1; LIN28; ZCCHC1; Protein lin-28 homolog B; LIN28B; Lin-28B; CSDD2
Gene ID
79727, 389421
Swiss Prot
9H9Z2, Q6ZN17
Cellular Locus
Cytoplasm, Nucleus
Host
Rabbit
Cross Reactivity
Mouse, Rat
Immunogen
75-180/209
Target
Lin28
Clonality
Polyclonal
Isotype
IgG
Conjugation
RBITC
Source
KLH conjugated synthetic peptide derived from human Lin28A
Applications
WB, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
570nm/595nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.biossantibodies.com/datasheets/bs-8443R-RBITC
Specificity
This antibody is produced using synthetic peptide that falls within the range of 90-120 amino acids of human Lin28A. Due to 92% sequence similarity, this antibody may cross react with Lin28B.
Gene ID URL
79727, 389421
Predicted Cross Reactivity
Human, Cow, Sheep, Pig, Horse, Rabbit
Curated Selection
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