PROTAC BRD9 Degrader-8
PROTAC BRD9 Degrader-8 (compound E5) is a PROTAC-based BRD9 degrader with a DC50 value of 16 pM. PROTAC BRD9 Degrader-8 has antiproliferation in MV4–11 cells (IC50 = 0.27 nM) and OCI-LY10 cells (IC50 = 1.04 nM) [1].
Product Specifications
CAS Number
3081180-48-2
UNSPSC
12352005
Target
PROTACs
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/protac-brd9-degrader-8.html
Smiles
O=C1C2=C(C(C3=CC(OC)=C(C(OC)=C3)CN4CCC(CN5CCC(CC5)C6=C7C(C8=CC=C7)=C(C=C6)N(C9C(NC(CC9)=O)=O)C8=O)CC4)=CN1C)C=CC=C2
Molecular Formula
C46H49N5O6
Molecular Weight
767.91
References & Citations
[1]Haiting Duan, et al. Discovery of a Highly Potent and Selective BRD9 PROTAC Degrader Based on E3 Binder Investigation for the Treatment of Hematological Tumors. J. Med. Chem. 2024, 67, 13, 11326–11353.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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