PANK1 Polyclonal Antibody, Cy3 Conjugated
Product Specifications
Background
The pantothenate kinase (PANK) family of proteins catalyzes the first step in coenzyme A (CoA) . Pantothenate kinase 1 (PANK1) is a 598 amino acid member of the pantothenate kinase family that plays a role in the physiological regulation of the intracellular CoA concentration. Localized to the cytoplasm, PANK1 is strongly inhibited by acetyl-CoA and manyl-CoA, as well as by high concentration of non-esterified CoA (CoASH) . Four known isoforms of PANK1 exist as a result of alternative splicing events. Of these isoforms, PANK1a and PANK1b have been identified as the catalytically active isoforms. Isoform PANK1a is most highly expressed in brain, heart, kidney, liver, skeletal muscle and kidney. Isoform PANK1b is detected at much lower levels in kidney, liver, brain and testis and is not detected in heart or skeletal muscle.
Synonyms
CoaA; hPanK; hPanK1; PANK; PANK1; PANK1_HUMAN; PANK1a; PANK1b; PanK1beta; Pantothenate kinase 1; Pantothenate kinase; Pantothenic acid kinase 1.
Gene ID
53354
Swiss Prot
Q8TE04
Cellular Locus
Cytoplasm
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
PANK1
Clonality
Polyclonal
Isotype
IgG
Conjugation
Cy3
Source
KLH conjugated synthetic peptide derived from human PANK1
Applications
WB, IF
Purification
Purified by Protein A.
Excitation Emission
512,550nm/570,615nm
Concentration
1µg/µl
Dilution
WB (WB=1:500-2000), IF (IF=1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
53354
Curated Selection
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