KIAA1199 Polyclonal Antibody, APC-Cy7 Conjugated
Product Specifications
Background
Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing.
Synonyms
CCSP1; TMEM2L; KIAA1199; Cell migration-inducing and hyaluronan-binding protein; CEMIP; HYBID
Gene ID
57214
Swiss Prot
Q8WUJ3
Cellular Locus
Cytoplasm, Nucleus, Secreted, Cell membrane, Extracellular matrix
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Immunogen
101-200/1361
Target
KIAA1199
Clonality
Polyclonal
Isotype
IgG
Conjugation
APC-Cy7
Source
KLH conjugated synthetic peptide derived from human TMEM2L
Applications
WB, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
650nm/780nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
57214
Predicted Cross Reactivity
Dog, Cow, Horse, Chicken, Rabbit
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