COMMD7 Polyclonal Antibody
Product Specifications
Background
COMMD is a new family of proteins with homology to MURR1, a multifunctional protein that inhibits NFkB. These proteins form multimeric complexes and were identified in a biochemical screen for MURR1-associated factors. The family is defined by the presence of a conserved and unique motif termed the COMM (copper metabolism gene MURR1) domain, which functions as an interface for protein-protein interactions. The prototype of this family, MURR1/COMMD1, suppresses NFkB by affecting the association of NF-kappaB with chromatin. COMMD7 (COMM domain-containing protein 7) interacts with COMMD1 via its COMM domain. It also associates with the NF-kappa-B complex and suppresses its transcriptional activity.
Synonyms
C20orf92; Chromosome 20 open reading frame 92; COMM domain containing 7; COMM domain containing protein 7; COMMD 7; dJ1085F17.3; FLJ14987; MGC33315; OTTHUMP00000030609; COMD7_HUMAN.
Gene ID
149951
Cellular Locus
Cytoplasm, Nucleus, Secreted, Extracellular matrix
Host
Rabbit
Immunogen
81-170/200
Target
COMMD7
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human COMMD7
Applications
ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
149951
Predicted Cross Reactivity
Human, Mouse, Rat, Dog, Pig
Curated Selection
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