AKR1A1/ALDR1 Polyclonal Antibody
Product Specifications
Background
Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN) .
Synonyms
Aldo-keto reductase family 1 member A1; Alcohol dehydrogenase [NADP (+) ]; Aldehyde reductase; Glucuronate reductase; Glucuronolactone reductase; AKR1A1; ALDR; ALR; AK1A1_HUMAN
Gene ID
10327
Swiss Prot
P14550
Cellular Locus
Cytoplasm, Secreted, Cell membrane, Extracellular matrix
Host
Rabbit
Cross Reactivity
Mouse, Rat
Immunogen
53-130/325
Target
AKR1A1/ALDR1
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human AKR1A1
Applications
WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
10327
Predicted Cross Reactivity
Human, Cow, Pig, Horse, Rabbit
Curated Selection
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