SNT-207858 (free base)

SNT207858 free base is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 free base has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor[1].

Product Specifications

CAS Number

[1104662-66-9]

UNSPSC

12352005

Target

Melanocortin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer; Metabolic Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/snt-207858-free-base.html

Concentration

10mM

Purity

99.66

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N1CCCC1)N[C@H](CC2=CC=C(Cl)C=C2Cl)C(N3CCC(C4=NC=CC=C4OC[C@H](N5CCCC5)CC)CC3)=O

Molecular Formula

C32H43Cl2N5O3

Molecular Weight

616.62

References & Citations

[1]Weyermann P, et al. Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice. PLoS One. 2009;4 (3) :e4774.