TNIK-IN-3

TNIK-IN-3 is a potent, selective and orally active inhibitor of Traf2- and Nck-interacting protein kinase (TNIK), with an IC50 of 0.026 μM. TNIK-IN-3 could also inhibit Flt4 (IC50=0.030 μM), Flt1 (IC50=0.191 μM) and DRAK1 (IC50=0.411 μM) . TNIK-IN-3 can be used for the research of colorectal cancer[1].

Product Specifications

CAS Number

[2754265-25-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

DAPK

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tnik-in-3.html

Purity

99.79

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

O=C1C2=CC=C(C=C2OCCN1CC3=CC=C(C=C3)F)C4=CC5=C(NC=C5)N=C4

Molecular Formula

C23H18FN3O2

Molecular Weight

387.41

Precautions

H302, H315, H319

References & Citations

[1]Li Y, et, al. Discovery of 3,4-Dihydrobenzo[ f][1,4]oxazepin-5 (2 H) -one Derivatives as a New Class of Selective TNIK Inhibitors and Evaluation of Their Anti-Colorectal Cancer Effects. J Med Chem. 2022 Jan 5.