TNIK-IN-3
TNIK-IN-3 is a potent, selective and orally active inhibitor of Traf2- and Nck-interacting protein kinase (TNIK), with an IC50 of 0.026 μM. TNIK-IN-3 could also inhibit Flt4 (IC50=0.030 μM), Flt1 (IC50=0.191 μM) and DRAK1 (IC50=0.411 μM) . TNIK-IN-3 can be used for the research of colorectal cancer[1].
Product Specifications
CAS Number
[2754265-25-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
DAPK
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tnik-in-3.html
Purity
99.79
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C1C2=CC=C(C=C2OCCN1CC3=CC=C(C=C3)F)C4=CC5=C(NC=C5)N=C4
Molecular Formula
C23H18FN3O2
Molecular Weight
387.41
Precautions
H302, H315, H319
References & Citations
[1]Li Y, et, al. Discovery of 3,4-Dihydrobenzo[ f][1,4]oxazepin-5 (2 H) -one Derivatives as a New Class of Selective TNIK Inhibitors and Evaluation of Their Anti-Colorectal Cancer Effects. J Med Chem. 2022 Jan 5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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