SIRT4 Polyclonal Antibody, AbBy Fluor™ 405 Conjugated
Product Specifications
Background
Acts both as NAD-dependent protein ADP-ribosyl transferase and NAD-dependent protein deacetylase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Down-regulates insulin secretion.
Synonyms
SIR2L4; NAD-dependent protein deacetylase sirtuin-4; NAD-dependent ADP-ribosyltransferase sirtuin-4; Regulatory protein SIR2 homolog 4; SIR2-like protein 4; SIRT4
Gene ID
23409
Swiss Prot
Q9Y6E7
Cellular Locus
Cytoplasm
Host
Rabbit
Cross Reactivity
Mouse
Immunogen
51-150/314
Target
SIRT4
Clonality
Polyclonal
Isotype
IgG
Conjugation
AbBy Fluor™ 405
Source
KLH conjugated synthetic peptide derived from human SIRT4/SIR 2 like protein 4
Applications
WB
Purification
Purified by Protein A.
Excitation Emission
401nm/421nm
Concentration
1µg/µl
Dilution
WB (1:300-5000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
23409
Predicted Cross Reactivity
Human, Rat, Cow, Sheep, Pig, Horse, Rabbit, Zebrafish, Fruit Fly
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
