DNA polymerase delta Polyclonal Antibody, APC Conjugated

DNA replication, recombination and repair, all of which are necessary for genomic stability, require the presence of exonucleases (1) . In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches (2) . These exonucleases include the family of DNA polymerases (3) . DNA pol , _, ∂ , and e are involved in DNA replication and repair (4) . DNA pol ∂ and DNA pol e are multisubunit enzymes, with DNA pol ∂ consisting of two subunits p125, which interacts with the sliding DNA clamp protein PCNA, and p50 (5) . The nuclear-encoded DNA pol © is the only DNA polymerase required for the replication of the mitochondrial DNA (6) . DNA pol is ubiquitously expressed in various tissues and mediates the cellular mechanism of damage-induced mutagenesis (7) . DNA pol œ is a DNA polymerase-helicase that binds ATP and is involved in the repair of interstrand crosslinks (8) .

DNA polymerase delta subunit 2; DNA polymerase delta subunit p50; DNA polymerase subunit delta 2; DNA polymerase subunit delta p50; DPOD2_HUMAN; POLD 2; POLD2.