RO60 Polyclonal Antibody, APC-Cy5.5 Conjugated

Ro autoantigens are of clinical significance because directed against them are found in most patients with primary Sjqgren syndrome, subacute cutaneous lupus erythematosus (SLE), neonatal lupus erythematosus, ANA-negative lupus erythematosus, and systemic lupus erythematosus-like disease secondary to homozygous C2 or C4 complement deficiency (1) . Ro/SSA is a ribonucleoprotein that binds to auto in 35 to 50% of patients with SLE and in up to 97% of patients with Sjqgren syndrome (2) . The Ro/SSA particle consists of a single immunoreactive protein noncovalently bound with one of four small RNA molecules (2) . Most anti-Ro/SSA-positive sera detect not only the main protein, but also a smaller Ro/SSA protein (2) . The genes which encode the smaller and larger proteins map to human chromosomes 11p15.5 and 1q31, respectively (3?) . La/SSB is an autoimmune RNA-binding protein that plays a role in the transcription of RNA polymerase III was originally defined by its reactivity with auto from patients with Sjren syndrome and SLE (6) .

TROVE2; 60 kDa ribonucleoprotein Ro; 60 kDa Ro protein; 60 kDa SS A/Ro ribonucleoprotein; 60 kDa SS-A/Ro ribonucleoprotein; Autoantigen Ro/SSA, 60-KD; bA101E13.2; Gastric cancer multi drug resistance protein; Ribonucleoprotein autoantigen SS A/Ro; RO 60; Ro 60 kDa autoantigen; RO60; RO60_HUMAN; RoRNP; Sjoegren syndrome antigen A2; Sjoegren syndrome type A antigen; Sjogren syndrome antigen A2 60kD ribonucleoprotein autoantigen SS A/Ro; Sjogren syndrome antigen A2 60kDa ribonucleoprotein autoantigen SS A/Ro; Sjogren syndrome antigen A2; SS A; SS-A; SS-A/Ro; SSA 2; SSA; SSA2; TROVE 2; TROVE domain family member 2; TROVE2.