PARP3 Polyclonal Antibody

Involved in the base excision repair (BER) pathway, by catalyzing the poly (ADP-ribosyl) ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.Tissue specificity: Widely expressed; the highest levels are in the kidney, skeletal muscle, liver, heart and spleen; also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus.

HPARP3; IRT1; NAD+ ADP ribosyltransferase 3; pADPRT 3; Poly[ADP ribose] synthetase 3; ADP ribosyltransferase NAD+; poly ADP ribose; ADPRT-3; ADPRT3; ADPRTL2; ADPRTL3; hPARP 3; hPARP-3; IRT 1; IRT1; NAD+ ADP-ribosyltransferase 3; NAD+ ADP ribosyltransferase 3; pADPRT-3; pADPRT3; PARP 3; PARP-3; PARP3; Poly ADP ribose polymerase family, member 3; Poly ADP ribose synthetase 3; Poly [ADP-ribose] polymerase 3; Poly[ADP-ribose] synthase 3.