Trk B Antibody

Product Specifications

Background

Tropomyosin-receptor-kinase (TRK) receptors are members of the receptor tyrosine kinase family and include TrkA, TrkB and TrkC. Each of these receptor types has different binding affinities to the neurotrophins nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT-3) . TrkB has the highest affinity to binding BDNF which plays critical roles in the function and survival of neurons in the CNS (Soppet et al., 1991; Klein et al., 1991) . Additionally, alterations in expression of TrkB have been associated with Alzheimer’s disease (Ferrer et al., 1999; Chen et al., 2008) .

Synonyms

AI848316 antibody, BDNF tropomyosine receptor kinase B antibody, BDNF/NT 3 growth factors receptor antibody, BDNF/NT-3 growth factors receptor antibody, Brain derived neurotrophic factor receptor antibody, C030027L06Rik antibody, EC 2.7.10.1 antibody, GP145 TrkB antibody, GP145-TrkB antibody, GP145-TrkB/GP95-TrkB antibody, GP95 TrkB antibody, Neurotrophic receptor tyrosine kinase 2 antibody, Neurotrophic tyrosine kinase receptor type 2 antibody, Neurotrophin receptor tyrosine kinase type 2 antibody, NTRK 2 antibody, Ntrk2 antibody, NTRK2_HUMAN antibody, Obesity hyperphagia and developmental delay included antibody, RATTRKB1 antibody, Tkrb antibody, Trk B antibody, Trk-B antibody, TRKB antibody, TrkB tyrosine kinase antibody, TRKB1 antibody, Tropomyosin related kinase B antibody, tyrosine kinase receptor B antibody, Tyrosine receptor kinase B antibody

Gene ID

25054

Swiss Prot

Q63604

Host

Rabbit

Cross Reactivity

Rat

Target

Trk B

Clonality

Polyclonal

Isotype

IgG

Conjugation

Unconjugated

Source

Synthetic peptide corresponding to amino acid residues from the C-terminal region of rat TrkB, conjugated to keyhole limpet hemocyanin (KLH) .

Applications

Purification

Affinity purification

Concentration

Lot Dependent

Dilution

WB (1:300-5000)

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Modification

Unmodified

Storage Conditions

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.